Ebf2 adipocyte
WebEBF2 determines and maintains brown adipocyte identity. Cell gating enzyme necessary for SUMOylation, this mouse model provides Metabolism 17(4):562e574. a valuable tool for understanding how the low-abundance post- [6] Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., et al., 2008. translational modification SUMOylation [49 ... National Center for Biotechnology Information
Ebf2 adipocyte
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Webfactor early B cell factor-2 (EBF2) promotes brown adipocyte differentiation, but its roles in maintaining brown adipocyte fate and in stimulating BAT recruit-ment during cold exposure were unknown. We find that the deletion of Ebf2 in adipocytes of mice ab-lates BAT character and function, resulting in cold intolerance. WebFigure 5. ZFP423 regulates EBF2 coregulator recruitment at EBF2 target genes. (A) Experimental design: iWAT SVF isolated from control or Zfp423-iAKO mice were induced to differentiate in vitro.Differentiated adipocytes were treated with 5 µM Dox for 12 h to inactivate Zfp423.Forty-eight hours after Dox treatment, cells were harvested for gene …
WebApr 2, 2013 · Ebf2 Is Required to Maintain the Expression of Brown-Specific Genes in Brown Adipocytes. (A) Phase contrast micrographs of brown adipocyte cultures 2 days … WebJan 1, 2016 · Results. We found that EBF2 is required for beige adipocyte development in mice. Subcutaneous WAT or primary adipose cell cultures from Ebf2 knockout mice did not induce Uncoupling Protein 1 (UCP1) or a thermogenic program following adrenergic stimulation. Conversely, over-expression of EBF2 in adipocyte cultures induced UCP1 …
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Webysis identified early B-cell factor 2 (Ebf2) as one of the most selec-tively expressed genes in this cell fraction. Importantly, Ebf2-expressing cells purified from Ebf2GFP embryos or …
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