WebDec 13, 2024 · Finally, the tumor xenograft model was applied to validation the role of SCARA5 tumor growth inhibition in vivo. We found that SCARA5 was aberrantly decreased in ESCC tissues and cell lines. ... Meanwhile, detecting the expression of SCARA5/FTL/FTH1 in the subcutaneous tumor nude mice in the control and … WebFerroptosis induced by lipid peroxidation is closely related to cancer biology. Prostate cancer (PCa) is not only a malignant tumor but also a lipid metabolic disease. Previous studies have identified ferroptosis as an important pathophysiological pathway in PCa development and treatment, but its role in the prognosis of PCa is less well known. In …
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WebSep 9, 2024 · Ferritin is a protein complex composed of two chains, light (FTL) and heavy (FTH), and its clinical importance has been demonstrated in many cancers through multiple roles: the contribution to tumorigenesis, the restoration of tumor-dependent vessel growth, and the association with tissue invasion ( Schonberg, 2015; Aversa et al., 2024 ). WebDec 1, 2024 · FTH1 Deferoxamine 1. Introduction Ferroptosis is a recently discovered non-apoptotic modality of regulatory cell death, which is driven by iron-dependent, lipid peroxidation, membrane damage, and cell lysis 1, 2, 3.
WebElevated expression of the iron regulatory protein, ferritin heavy chain 1 (FTH1), is increasingly being associated with high tumor grade and poor survival outcomes in glioblastoma. Glioma initiating cells (GICs), a small population of stem-like cells implicated in therapeutic resistance and glioblastoma recurrence, have recently been shown to ... WebJan 29, 2024 · Similarly, the induction of ferritinophagy-dependent ferroptosis in many cancer types with high levels of FTH1 and/or FTL expression (such as PDAC and ovarian cancer) may hold promise ...
WebMar 17, 2024 · 50 Citations 1 Altmetric Metrics Abstract Ferroptosis is a newly recognised type of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid peroxidation. It is... WebApr 11, 2024 · Esculetin was only proven to induce ferritinophagy in liver cancer cells via the NCOA4/LC3II/FTH1 pathway, but it is uncertain whether esculetin promotes ferritinophagy via other pathways or if it inhibits other cancers. Future experiments should investigate various cancers and pathways to better study esculetin’s antitumor …
WebXiangyang Tian, 1 Shuyuan Li, 2 Guoyan Ge 2 1 Department of Oncology, Peace Hospital, Changzhi Medical College, Changzhi, Shanxi Province, 046000, People’s Republic of China; 2 Department of Tumor Spleen and Stomach, Hospital of Traditional Chinese Medicine of Changzhi City, Changzhi, Shanxi Province, 046013, People’s Republic of China …
WebMar 3, 2024 · “MMRi62 causes degradation of an iron-storage protein called FTH1, as well as a protein that is mutated in PDAC, resulting inhibition of metastasis and ferroptosis, a form of cell death triggered by free cellular iron,” says Xinjiang Wang, PhD, Associate Professor in the Department of Pharmacology and Therapeutics at Roswell Park. potawatomi indians homesWebSep 21, 2024 · FTH1, a key subunit of ferritin, is involved in a variety of disease signaling pathways. In particular, the expression of FTH1 varies in different diseases. FTH1 was shown to regulate immunity in studies of prostate and breast cancer [37, 38]. FTH1 has been shown to inhibit apoptosis through the JNK signaling pathway activity . potawatomi indians gaming regulatory actWebOverexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple-negative subtype (triple-negative breast … potawatomi inn and cabinsWebDec 1, 2024 · FTH1 was a key determinant for baicalin-induced ferroptosis. (A) The expression of FTH1 and transferrin was detected by Western blotting. (B) Untransfected … potawatomi jobs applicationsWebJul 12, 2024 · Recent studies have demonstrated that ferroptosis is a good method for tumor treatment, and iron homeostasis is closely associated with ferroptosis. Iron regulatory protein (IRP)1 and 2 play important roles in maintaining iron homeostasis, but their functions in ferroptosis have not been investigated. potawatomi inn reservationsWebApr 13, 2024 · Cancer is a heterogeneous disease. As such, a systemic view of cancer as an evolving ecosystem, rather than a singular view of specific cell type or gene, is essential to guide a more effective ... potawatomi inn and resortWebMay 12, 2024 · The reporter gene ferritin heavy chain (FTH1) was modified by adding a promoter from the tumor-specific gene progression elevated gene-3 (PEG3) and transduced into MSCs to obtain MSCs-PEG3-FTH1. potawatomi inn and conference center